Therapeutic Plasma Exchange in Treatment of Autoimmune Encephalitis: A Case Report

The present study highlights the Therapeutic Plasma Exchange in treatment of Autoimmune Encephalitis. Due to the similarities in the clinical, imaging, and laboratory findings of many forms of autoimmune and infectious encephalitis, autoimmune encephalitis is frequently a difficult clinical diagnosis. Diagnosis of autoimmune encephalitis is based on the clinical course, serological evidence of autoimmunity, EEG changes, evidence of intrathecal inflammation in the cerebrospinal fluid and neuroimaging by MRI. In view of the suspected diagnosis of Autoimmune Encephalopathy with super refractory Status Epilepticus, Methylprednisolone was later added to the treatment. This case represents an interesting scenario of sero-negative encephalitis in which an early diagnosis could be made and treatment initiated in time.