Obesity: Multiple Biological Factors

Obesity is one of the major challenge of modern society which will lead to other health problems. Recently, researches have been conducted to understand the correlation between obesity and type of gut microflora with the objective to control severe health diseases by changing gut flora or diet. Researches also have been conducted to understand the relationship of serum leptin and obesity. Leptin is a hormone produced by white adipose tissue that acts as a satiety factor sending signals of nutritional status to the hypothalamus. Both gut microflora, as well as serum leptin, have shown significant associations with obesity individually and in relation to each other. However due to the great heterogeneous and complex nature of obesity, the question regarding their interaction with each other remains unclear. The objective of review are, firstly to identify the role of gut microflora & serum leptin; secondly, to analyse the interaction of gut microflora and serum leptin in the obese phenotype and lastly, to discuss the therapeutic benefits of gut microflora modulation for serum leptin.