Roles of Chitosan Nanoparticles on Ehrlich Ascites Carcinoma Induced Changes in Some Blood Parameters

Background and Objective: Chitosan, the deacetylated derivative of chitin, is a natural D-glucosamine polymer that can be extracted from the shells of seafood such as lobsters and prawns crabs which have obtained a great interest in cancer therapy. This study aimed to investigate the hepatic and renal protective potential of chitosan nanoparticles (CNPs) against Ehrlich ascites carcinoma (EAC)–bearing mice- induced blood toxicity.

Materials and Methods: A total of 40 female mice were divided into 4 groups (1st group, control group; 2nd group, CNPs group; 3rd group, EAC group; 4th group, co-treated EAC with CNPs).

Results: Results showed that the presence of CNPs in co-treated groups lead to decreased cholesterol, triglyceride, urea, creatinine, AST, ALT, ALP, potassium and chloride ions levels while showed increased total protein, albumin, sodium and calcium ions levels compared to EAC group.

Conclusion: The present study confirmed that chitosan nnp has a protective potential effect against EAC cell induced blood toxicity toxicity.