Antioxidant and Alpha Amylase Inhibitory Activity of Apigenin in Alloxan Induced Diabetic Rats

Purpose: to study the antioxidant, inhibitory activity of alpha amylase, antidiabetic, effects of flavonoid Apigeninin in diabetic rats.

Methods: The effect of Apigeninon on blood glucose and antioxidant activities were estimated in alloxan induced diabetic and treated rats. The α-amylase inhibitory activity in the serum was assessed after oral administration of 7thday, 14th day, and 21st days treatment of Apigenin.

Results: The Apigenin was reduced the serum glucose, α-amylase levels and increased antioxidant levels significantly (P<0.05) in Apigenin alone and combination with Metformin treated groups.

Conclusion: The present investigation concludes that flavonoid Apigenin, single drug and combination with Metformin was increased antioxidant and inhibited the alpha-amylase activity and hypoglycemic effect in alloxan induced diabetes rats.