The impact of icodextrin on the outcomes of incident peritoneal dialysis patients

Wang, I-Kuan and Chan, Chan Ip and Lin, Alfred Hsing-Fen and Yu, Tung-Min and Yen, Tzung-Hai and Lai, Ping-Chin and Li, Chi-Yuan and Sung, Fung-Chang and Shah, Ankur (2024) The impact of icodextrin on the outcomes of incident peritoneal dialysis patients. PLOS ONE, 19 (3). e0297688. ISSN 1932-6203

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Abstract

Objective
The aim of the study is to investigate the effects of icodextrin on the risks of death, technique failure and the first episode of peritonitis in peritoneal dialysis (PD) patients.

Methods
From medical records of a medical center in Taiwan, a total of 725 newly diagnosed end-stage kidney disease patients receiving PD for at least 90 days from January 1, 2007 to December 31, 2018 were identified. These patients were grouped as 190 icodextrin users and 535 non-users. Users were defined as utilization of icodextrin for ≥ 50% of their PD duration. The use of icodextrin was considered a time-varying exposure in the Cox proportional hazard model. The risks of death, technique failure and the first episode of peritonitis were compared between two cohorts by the end of 2018.

Results
Compared to the non-users, the icodextrin users had significant lower risks of mortality (6.5 vs.7.2 per 100 person-years; adjusted HR = 0.62, 95% CI = 0.42–0.91) and technique failure (12.7 vs. 15.2 per 100 person-years; adjusted HR = 0.61, 95% CI = 0.47–0.81), and the first peritonitis episode (5.0 vs. 17.0 per 100 person-years; adjusted HR = 0.22, 95% CI = 0.14–0.35). The risk of peritonitis reduced further in icodextrin users with diabetes and with cardiovascular disease.

Conclusion
Icodextrin was associated with lower risks of mortality, technique failure, and the first episode of peritonitis.

Item Type: Article
Subjects: Archive Paper Guardians > Biological Science
Depositing User: Unnamed user with email support@archive.paperguardians.com
Date Deposited: 01 Apr 2024 07:49
Last Modified: 01 Apr 2024 07:49
URI: http://archives.articleproms.com/id/eprint/2719

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