Role of Indian Spices and Biotherapeutics in Managing Chronic Disease

The acceleration in the rate of chronic disease that involves insulin resistance has become of concern in various countries. The rate of most prevalent chronic diseases involve metabolic syndrome and non-alcoholic fatty liver disease (NAFLD) which is closely associated with diabetes and neurodegenerative diseases. The primary aim of the study is to review the role of Indian spices and biotherapeutics in health and chronic disease. Databases searched for medical literature in this study include Pubmed database, Medline database, Research Gate Researcher Network, Mendeley Research Network and Academia.edu. Biotherapeutics and nutritional biotherapy have become important to reverse these global diseases. Drug biotherapeutics are essential to stabilize chronic disease with dietary interventions and fat consumption that determine biotherapeutics important to the treatment of endocrine and metabolic diseases. Biotherapeutics that involves Indian spice therapy requires assessment with relevance to insulin therapy, immunotherapy, antimicrobial therapy and drug therapeutics. Combined insulin therapy and Indian spice therapy regulate human insulin biological activity with relevance to the prevention of uncontrolled intracellular glucose levels and mitochondrial apoptosis. Biotherapeutics with nutritional biotherapy that involves the use of various nutrients such as magnesium and phosphatidylinositol (gm/day) is essential to insulin therapy. Factors such as stress, core body temperature and food quality influence biotherapeutics and Indian spice therapy with delayed spice clearance associated with mitochondrial dysfunction (cell apoptosis) and altered drug/caffeine therapy with relevance to the global diabetes pandemic. Monitoring of long-term Indian spice therapy may be required in future clinical trials in men with relevance to safety compared to diabetic individuals with insulin therapy and without Indian spice therapy.