In silico ANALYSIS OF PHYTOCHEMICALS FROM Bacopa monieri AGAINST PEPTIC ULCER CAUSED BY Helicobacter pylori

Presently, the herbal product usage increased tremendously worldwide. Bacopa monnieri is one of the medicinal plant which has been consumed by human for thousands of year as a memory enhancer, anti-inflammatory drug, anti-epileptic drug, analgesic, anti-pyretic drug and as a sedative. Several commercial and medicinal research have been focusing their resources on this plant. This plant has been known to possess several activities such as anti-bacterial, anti-fungal, anti-cancer, anti-oxidant, anti-inflammatory, anti-depressant, anti-epileptic, memory enhancer, anti-ulcer, hepatoprotective, analgesic, anti-diarrheal, anti-hypertensive, anti-toxicity etc. [1]. Phytochemicals are non-nutritive compounds obtained from plants. It has been reported that Bacopa monnieri plant extract is used to cure peptic ulcer. The plant extract contains different phytochemicals. Peptic ulcer is caused by Helicobacter pylori. One of the key enzymes involved in its biochemical pathway is alcohol dehydrogenase. The molecular docking of the phytochemicals with the enzyme was studied using Biovia Discovery Studio. The strength of the interaction was evaluated based on -CDOCKER energy and -CDOCKER interaction energy. High positive values for both the parameters indicated that out of different phytochemicals Apigenin, D-Mannitol, Luteolin, Nicotine can effectively deactivate the enzyme there by interrupting the life cycle of Helicobacter pylori.