Photo Degradation of Ketoprofen Using Titanium Dioxide as Catalyst

Research on the degradation of pure ketoprofen and tablets by means of photolysis using ultraviolet
light and titanium dioxide catalysts has been performed. Ketoprofen and its degradation results were
analyzed by ultraviolet spectrophotometers at 260 nm and high-performance liquid chromatography.
Degradation of ketoprofen is done by photolysis using ultraviolet A (366 nm) and ultraviolet C (254
nm) lamps using titanium dioxide (TiO2) as catalysts at various concentrations, mass and time. The
percentage degradation of pure ketoprofen and tablets using UV A photolysis method and TiO2 15
mg as catalyst was 51.04% and 48.11%, respectively, after 180 min. The percentage degradation of
pure ketoprofen and tablets using UV C photolysis method and TiO2 15 mg as catalyst was 91.08 %
and 89.11%, respectively, after 120 min. The results showed that photolysis method with UV C was
better to degrade ketoprofen than UV A with the addition of TiO2 as catalyst. The residual analysis of
ketoprofen was performed by high performance liquid chromatography using C18 column (150 mm x
4.6 mm), the mobile phase was acetonitrile: 0.2 % acetic acid (45: 55), the flow rate was 1.2 mL / min.
Chromatogram showed a decrease in peak ketoprofen and the emergence of new peaks during
ketoprofen degradation process.