Anti-Arthritis, Antioxidant and Anti - Inflammatory Potential of Ethanolic Extract of Guava Leaves on Rats Exposed to High Fat Diet and Freud Adjuvant

Chinatu, Nwosu Patience and Elekima, Ibioku and Adeline, Ben-Chioma and Holy, Brown (2023) Anti-Arthritis, Antioxidant and Anti - Inflammatory Potential of Ethanolic Extract of Guava Leaves on Rats Exposed to High Fat Diet and Freud Adjuvant. Journal of Complementary and Alternative Medical Research, 24 (3). pp. 46-53. ISSN 2456-6276

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Abstract

Guava leaves (Psidium guajava) have been used traditionally for years to treat common ailments such as Diabetes, diarrhoea, and hypertension. This study was designed to determine the anti-arthritic, anti-inflammatory, and antioxidant effect of the ethanolic extract of guava leaf (Psidium guajava) on rats fed with a high-fat diet and induced arthritis using complete Freud Adjuvant. Seventy-two male and female albino rats were used in this study, the rats were grouped into 12 with 6 rats in each group, rats were fed a high-fat diet to cause hyperlipidaemia and induced rheumatoid arthritis by injecting 0.1ml of Complete Freund’s Adjuvant into their right hind paw. Group 1 was fed with normal feed and water, group 2 was made of healthy rats, fed with normal feed, water, and guava leaf extract, group 3 was fed with a high-fat diet and induced arthritis with complete Freund’s Adjuvant (CFA) and water, group 4 received dexamethasone (6.75 mg.kg-1 orally), and groups 5 to 12 received the extract at oral doses of 250 and 750 mg/kg, respectively for a period of 28days. ELISA technique was used to analyse the inflammatory markers, antioxidants; SOD, and MDA, while the lipid profile was on a spectrophotometer. The inflammatory markers TNF-α, IL-6, and C-reactive protein were significantly reduced in test subjects at p<0.05, HDL and SOD had no statically significant difference, while MDA was markedly reduced at p<0.05. This study demonstrates that Psidium guajava extract has significant anti-arthritic and lipid-lowering effects. Psidium guajava leaves can be developed into an alternative anti-arthritis and lipid-lowering treatment.

Item Type: Article
Subjects: Archive Paper Guardians > Medical Science
Depositing User: Unnamed user with email support@archive.paperguardians.com
Date Deposited: 22 Nov 2023 05:46
Last Modified: 22 Nov 2023 05:46
URI: http://archives.articleproms.com/id/eprint/2344

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