ANTIMICROBIAL ACTIVITY OF GINGER (Zingiber officinale) EXTRACTS AGAINST Klebsiella pneumoniae ‎ AND Pseudomonas aeruginosa

This study was designed to investigate the antibacterial activity of ginger (Zingiber officinale) on Klebsiella pneumoniae and Pseudomonas aeruginosa. Four different extracts were obtained from ginger rhizome by four solvents (Water, Chloroform, Ethanol, and Petroleum ether). Six different concentrations of each extract (10 mg/ml, 15 mg/ml, 25 mg/ml, 50 mg/ml, 100 mg/ml, and 150 mg/ml) in DMSO (Dimethyl sulfoxide) solvent were used with three different concentrations (50 mg/ml, 100 mg/ml, and 150 mg/ml) of ix known antibiotics (Tetracycline, Cloxciline, Cephalin, Ampicillin, Amoxicillin, and Neomycin).Tetracycline, and Neomycin, show best activity against; Klebsiella pneumoniae ‎ and Pseudomonas aeruginosa.

The antibacterial activity of different ginger extracts and their concentrations by different types of solvents showed considerable antibacterial activity against Klebseilla pneumonia and Pseudomonas aruginosa as described by the zones of inhibition which also depend on their concentration, with the same trends of the antibiotics used in this work. From the results obtained from this work we could conclude that dinger extracts by organic solvents or even water may be used for the treatment of Klebseilla pneumoniae and Pseudomonas aeruginosa infections, or may be used for synergistic partner to other antibiotic drugs.