Effects of Different Exercise Strategies and Intensities on Memory Performance and Neurogenesis

Diederich, Kai and Bastl, Anna and Wersching, Heike and Teuber, Anja and Strecker, Jan-Kolja and Schmidt, Antje and Minnerup, Jens and Schäbitz, Wolf-Rüdiger (2017) Effects of Different Exercise Strategies and Intensities on Memory Performance and Neurogenesis. Frontiers in Behavioral Neuroscience, 11. ISSN 1662-5153

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Abstract

It is well established that physical exercise affects both hippocampal neurogenesis and memory functions. Until now, distinctive effects of controlled and voluntary training (VT) on behavior and neurogenesis as well as interactions between exercise intensity, neurogenesis and memory performance are still elusive. The present study tested the impact of moderate controlled and VT on memory formation and hippocampal neurogenesis and evaluated interactions between exercise performance, learning efficiency and proliferation of progenitor cells in the hippocampus. Our data show that both controlled and VT augmented spatial learning and promoted hippocampal neurogenesis. Regression analysis revealed a significant linear increase of the amount of new hippocampal neurons with increased exercise intensity. Regression analysis of exercise performance on retention memory performance revealed a quadratic, inverted u-shaped relationship between exercise performance and retention of spatial memory. No association was found between the amount of newborn neurons and memory performance. Our results demonstrate that controlled training (CT), if performed with an appropriate combination of speed and duration, improves memory performance and neurogenesis. Voluntary exercise elevates neurogenesis dose dependently to high levels. Best cognitive improvement was achieved with moderate exercise performance.

Item Type: Article
Subjects: Archive Paper Guardians > Biological Science
Depositing User: Unnamed user with email support@archive.paperguardians.com
Date Deposited: 23 Feb 2023 11:37
Last Modified: 02 Oct 2023 12:42
URI: http://archives.articleproms.com/id/eprint/190

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