A Case Study about Peripheral Blood Plasmacytosis Mimicking a Plasma Cell Neoplasm

We present the case of an elderly male patient with an infection-related plasmacytosis that mimicked a neoplastic process. For two distinct reasons, plasmacytosis may be regarded as having clinical significance: 1. It must be distinguished from a malignant plasmacytic illness. 2. Evaluation of its diagnostic and clinical relevance is necessary. Infectious diseases have the potential to produce an increase in the number of plasma cells in the blood. It may raise the possibility of a plasma cell neoplasm being present. Plasma cells reduce in the peripheral circulation before disappearing entirely. Infections, malignancies, and autoimmune illnesses are just a few of the factors that can cause reactive plasmacytosis. In summary, regardless of the patient's age, laboratory doctors and clinicians should consider infection-related plasmacytosis in the differential diagnosis of plasma cell dyscrasia before moving forward with a thorough and invasive evaluation like BME and other pricey tests, especially in settings with limited resources.