Antioxidant, Antihemolytic, Antihyperuricemic, Anti-inflammatory Activity of Algerian Germander Methanolic Extract

The presence of osteochondrosis in a body negatively influences many blood indices. At the given state we consider to be very interesting some peculiarities of erythrocytes’ rheological characteristics which determine the processes of microcirculation and metabolism in tissues. Detection of their state at developing osteochondrosis can help in a fuller understanding of its progression mechanisms and search of variants of the given process’ inhibition. The aim is to estimate erythrocytes’ microrheological properties in people of the second mature age with osteochondrosis of the 2nd degree. Within our research, we took 37 healthy persons of both sexes of the second mature age and also 43 people of both sexes of the same age with osteochondrosis of the 2nd degree. We applied biochemical, hematological and statistical methods of investigation. The quantity of acylhydroperoxides and thiobarbituric acid-products in plasma of the examined persons with osteochondrosis surpassed the control values by 38.4% and 37.4%, respectively. It was accompanied by imbalance of metabolites of arachidonic acid: the level of thromboxane B2 in their plasma rose by 30.6%, and the level of 6-keto-prostaglandin F1α lowered by 15.9%. At the same time, the quantity of nitric oxide metabolites in their plasma lowered by 23.6%. The quantity of acylhydroperoxides in their erythrocytes rose by 30.0% and malon dialdehyde – by 36.7%. The people with osteochondrosis were noted to have content lowering of erythrocytes-discocytes in blood by 12.7%. At the same time, the quantity of reversibly and irreversibly changed erythrocytes’ forms in them increased by 35.7% and in 2.5 times, respectively. Erythrocytes’ aggregative properties in people with osteochondrosis turned out to be strengthened. It was pointed by the increase of erythrocytes’ summary involvement into aggregates by 32.9% in them and number growth of these aggregates - by 33.3%. People of the second mature age with osteochondrosis of the 2nd degree are characterized by strengthening of lipid peroxidation processes in plasma and erythrocytes. It is accompanied by worsening of erythrocytes’ microrheological properties. Given changes can negatively influence the processes of microcirculation and worsen the trophism of tissues, including spinal column, what promotes progression of osteochondrosis. So, it is necessary to search the variants of inhibition of osteochondrosis progression and lowering of its manifestations’ sharpness. At the same time, it’s very important to take into account the capacities of the tested medicinal approaches. Their impact on erythrocytes’ microrheological properties can be rather great.