Autoimmune Progesterone Dermatitis with Post-Inflammatory Hyperpigmentation

Autoimmune Progesterone dermatitis is a rare disorder characterized by recurrent cyclical cutaneous eruptions during the menstrual period, and is due to hypersensitivity to progesterone. It is a dermatosis with myriad modes of presentation including urticaria, eczema, papulovesicles, angioedema, anaphylaxis, pruritus and erythema multiforme. We hereby present the first documented report from Nigeria - the case of a 35 year old woman with recurrent premenstrual eruption of erythematous patches, papulovesicular and urticated lesions with attendant distressing post-inflammatory hyperpigmented spots. Diagnosis was confirmed by the typical premenstrual cyclical presentation and a positive progesterone challenge test.