Case Report of Attenuated-Responsiveness to Coartem® in Western Kenya

Kamau, Edwin and Akala, Hoseah M. and Achieng, Angela O. and Yeda, Redemptah and Ingasia, Luicer A. and Cheruiyot, Agnes C. and Juma, Dennis W. and Okudo, Charles and Omariba, Duke and Muriuki, Catherine and Owiti, Eunice A. and Omondi, Patrick and Otedo, Amos and Andagalu, Ben and Ogutu, Bernhards (2014) Case Report of Attenuated-Responsiveness to Coartem® in Western Kenya. International Journal of Medical and Pharmaceutical Case Reports, 2 (1). pp. 5-9. ISSN 2394109X

[thumbnail of Kamau212014IJMPCR11141.pdf]

Text
Kamau212014IJMPCR11141.pdf - Published Version
Download (207kB)

Official URL: https://doi.org/10.9734/IJMPCR/2015/11141

Abstract

We describe a case of attenuated-responsiveness to Artemether-Lumefantrine (AL) in western Kenya. A 4-year old patient with 14% parasitemia was treated with Coartem® but on day 7 still had 5% parasitemia. Parasite genetic profile had similar genetic polymorphism as that selected for when AL is administered. In vitro analysis revealed elevated IC50s for AL components compared to the reference P. falciparum clone 3D7 and samples collected at this site over the last 5 years. There is need for continued global surveillance to effectively manage emergence and spread of artemisinin drug resistance which has now been found in Southeast Asia.

Item Type:	Article
Subjects:	Archive Paper Guardians > Medical Science
Depositing User:	Unnamed user with email support@archive.paperguardians.com
Date Deposited:	15 Jul 2023 05:51
Last Modified:	31 Jan 2024 04:27
URI:	http://archives.articleproms.com/id/eprint/1147

Actions (login required)

: View Item